Relentless Research for the Rarest Cancers
Rare But Relentless Foundation brings together patients, families, researchers, and supporters to accelerate research and create hope for people affected by ultra-rare sarcomas and other ultra-rare cancers.
We focus on the cancers that are often overlooked, so no one is left behind by science.
Why We Exist
Ultra-rare cancers often lack critical funding and data, leaving patients without treatments. We believe no diagnosis is too rare for science. Our mission is to provide the visibility and research these patients deserve, turning rarity into discovery.
Our Current Research Focus
Our initial focus is on CIC-rearranged sarcoma and other ultra-rare undifferentiated round cell sarcomas, including BCOR-altered and EWSR1–non-ETS fusion sarcomas. By concentrating on these overlooked cancers, we aim to build the evidence, data, and collaborations needed to drive better understanding and better options for patients.
Fund promising laboratory research
Support research using genomics and AI to help uncover the biology, biomarkers, and treatment vulnerabilities of ultra-rare cancers.
Connect patients, researchers, and data
Bring together patients, clinical insights, and data to strengthen ultra-rare cancer research.
How We Advance Research
Build Research PartnersÂ
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Connect top researchers, institutions, and industry partners to accelerate discovery.
Accelerate Translation to TreatmentÂ
Help move promising discoveries toward clinical trials and new treatment options.
Our Story
Rare But Relentless Foundation was born from our founder Zach Rothschild’s own journey with CIC-rearranged sarcoma. Witnessing the critical gaps in care, Zach Rothschild launched this mission to catalyze the research, collaboration, and treatment development ultra-rare cancers urgently need. We are committed to ensuring that no patient is left behind by science, transforming lived experience into a relentless engine for discovery.
Newly Diagnosed Support
Helping patients and families navigate an ultra-rare diagnosis through trusted resources, leading experts, and community.
For Patients and Families
If you or someone you love is facing an ultra-rare sarcoma or other ultra-rare cancer, you are not alone. Our patient community helps you find information, connection, and ways to participate in research if and when you’re ready.
Patient Network & Registry Interest
Opportunities to join our patient network and registry interest list so your experience and data can help drive better research.
Share Your Story
Tell your story to increase awareness and provide experts with vital understanding of living with a rare disease.
Get Involved
Everyone has a role to play in changing the future of ultra-rare cancers.
Donate to fuel high-impact research.
Start a fundraiser in honor of someone you love.
Volunteer your time or expertise.
Partner with us as an institution, organization, or company.
Share your story to raise awareness and inspire others.